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A dual GLP-1 agonist (tirzepatide) activates both the GLP-1 and GIP receptors

Planning meal timing and injection schedule accordingly might help manage symptoms

Overall, results from the cardiovascular outcomes trials (CVOTs) completed for all marketed GLP-1 RAs in type 2 diabetes support a benefit in HF specifically in addition to the approved use in broad CVD risk reduction in people with type 2 diabetes (Sattar et al., 2021)

"Retinol became the gold standard not because it was the best option, but because it was the first one with solid clinical data

When taken in recommended doses, cyanocobalamin is typically well-tolerated during pregnancy

The approach to participant selection underpinned the study's objective to delineate the specific contributions of GLP-1 therapies to clinical outcomes within a real-world context, ensuring comparability and minimizing confounding across cohorts