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Above 500mg daily, constipation incidence rises sharply affecting 2530% of users at 5001000mg and nearly 50% above 1500mg

The peptides small size and charge profile allow it to penetrate the stratum corneum, though penetration efficiency depends heavily on the vehicle

Yan H-D, Ishihara K, Serikawa T, Sasa M (2003) Activation by N-acetyl-L-aspartate of acutely dissociated hippocampal neurons in rats via metabotropic glutamate receptors