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N-acetylcysteine (NAC) was introduced in the 1960s as a mucolytic drug for chronic respiratory diseases

doi: 10.1038/s41419-023-06042-1 25 BuschhausJMRajendranSHumphriesBACutterACMuizAJCiavattoneNGet al

also identified ad G6PDH) and 6-phosphogluconate dehydrogenase (PGD) both generate one mole of NADPH for every mole of glucose-6-phosphate that enters the PPP

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Marins 3 , Kaili Ren 3 , Marco Vilela 3 , Thikshaya Mahendran 4 , Amanda Sees 2 , May Hagiwara 3 and Rohit Loomba 5 , (1)University of Florida, Gainesville, FL, USA, (2)Iqvia, Plymouth Meeting, PA, USA, (3)Takeda Development Center Americas, Inc., Cambridge, MA, USA, (4)Iqvia, Bengaluru, India, (5)University of California, San Diego, San Diego, CA Background: Diagnosis (dx) of alpha-1 antitrypsin deficiency (AATD)-associated liver disease (LD) is challenging due to the variable risk and asymptomatic nature of the disease