PMID: 24717514 View source Ulanovskaya OA, et al
This element is naturally formed and synthesized in the liver from 3 amino acids - Cysteine, Glycine and Glutamic Acid
However, it is not entirely certain how many of these patients met ME/CFS criteria, suggesting that replication studies should be done in future to help us understand the genes, cellular processes, and tissues or cells that causally change the risk for developing ME/CFS
Liver (hepatic) and kidney safety considerations are equally important, since some supplements that undergo hepatic metabolism or renal excretion can accumulate or interact with chemotherapeutic drugs leading to hepatotoxicity (e.g., kava, high-dose green tea extract) or nephrotoxicity in patients who already suffer from impaired organ function or taking chemotherapy agents known to be nephrotoxic such as cisplatin (208, 209)
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However, for those supplementing, high B12 levels are generally a reflection of recent supplementation, not a cause for concern