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10.5214/ans.0972.7531.220406 46 NagaokaT.TakashiS.FumihikoM.EiichiS.AkitoshiY

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Under pro-inflammatory conditions, as evidenced by interventions with LPS or IFN-, microglia are insensitive to ferroptosis, yet susceptible to iron overload ( in vitro data showed that genetic depletion of iNOS renders Raw264.7 cells and EOC 20 cells vulnerable to ferroptosis, whereas NO donors (SNAP, DPTA-NONOate) empower the ferroptotic resistance of M2 microglia (43)

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