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Activation of the P38 MAP kinase pathway is required for foam cell formation from macrophages exposed to oxidized LDL

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Nanomedicine platforms offer precise tools for macrophage modulation, enabling the targeted delivery of polarization-inducing agents directly to the TME while sparing peripheral tissues (4750)accompanied by the robust activation of the NF-B and STAT1 pathways that drive the transcription of pro-inflammatory cytokines and immunostimulatory factors (51, 52)