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Those results were published in 2022 in Brain Research Bulletin
Many compounded tirzepatide formulations already include B12 for this reason
Joukar S
In the obese trial cohort, 1 mg moved 24-hour ambulatory heart rate by +0.7 bpm at week 24 the peak of the heart-rate curve, and below the placebo arms +0.8. In a healthy lean Phase 1 group, the same dose raised heart rate by about 10 bpm, with a peak near 15 to 20 bpm around days 4 to 6. Lean, younger participants had more reactive heart-rate control than the sedentary, obese, and metabolically stressed trial population
This color variation may not affect how the medication works in the body
The choice among these approaches depends entirely on the specific research question, the preferred administration route, and the research timeline being studied
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