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In certain specialist settings, metformin may occasionally be considered for conditions such as polycystic ovary syndrome (PCOS) or prediabetes where weight management is clinically important, but this represents individualised care rather than routine practice
In short, these agencies set a de facto global value floor: drug prices deemed too high to be cost-effective by NICE or ICER will pressure manufacturers to reduce worldwide or face limited access
It is prescribed and monitored by a physician, and it sits alongside nutrition, lifestyle, and regular follow-up
Other important safety considerations include: Risk of acute pancreatitis : Seek urgent medical attention for severe, persistent abdominal pain with or without vomiting [1] Gallbladder disease : Increased risk of gallstones and related complications Diabetic retinopathy : Caution in patients with pre-existing retinopathy due to rapid improvement in blood glucose control Hypoglycaemia : Increased risk when used with insulin or sulfonylureas, which may require dose reduction of these medications Oral contraceptive interaction : Reduced effectiveness due to delayed gastric emptying
