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doi: 10.1158/1078-0432.CCR-15-1883 128 TerrnIOrrantiaAVitallJZenarruzabeitiaOBorregoF

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Semaglutide in the context of the broader GLP-1 landscape Semaglutide does not exist in isolation

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Unlike many peptides that act through a single well-defined receptor, GHK-Cu exerts its biological effects through multiple mechanisms including direct stimulation of collagen and glycosaminoglycan synthesis, activation of antioxidant enzymes, modulation of metalloproteinase activity, promotion of angiogenesis, and broad regulation of gene expression across hundreds of genes involved in tissue repair, inflammation, and cellular protection

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