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TRIUMPH-4 (Phase 3, 68 weeks) 12mg dose: 28.7% weight loss (~71 lbs / 32 kg average) 9mg dose: 26.4% weight loss (~64 lbs / 29 kg average) Patients also saw 76% reduction in knee osteoarthritis pain Blood pressure reduced by 14 mmHg on average Source: ClinicalTrials.gov (TRIUMPH-4, NCT05931367) The TRIUMPH Phase 3 program includes 4 trials studying retatrutide for obesity, type 2 diabetes, and cardiovascular outcomes
GLP-1 weight loss is not appropriate for everyone
Temperature excursions can degrade the peptide, reducing potency or creating breakdown products that may cause adverse reactions
Reflections on disadvantages of the use of free fatty acids as fuel for brain
GHK-Cu is a different peptide entirely, generally associated with wound healing and collagen support rather than pigment production
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