A small clinical imaging study in Parkinsons disease patients showed that intranasal glutathione could raise brain glutathione levels within 20 to 45 minutes, although the amount and duration varied widely among individuals
Other authors have also studied the relationship between glutathione levels and skin pigmentation
Glutathione may be depleted by chronic inflammation, ongoing immune activation, elevated toxic body burden, and high levels of oxidative damage
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So statements that topical AHK-Cu is "well tolerated" rest on the copper-peptide class generally much of it built on GHK-Cu (Pickart & Margolina 2018, PMID 29986520) and on community use, rather than on dedicated AHK-Cu safety study