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The findings were published in JAMA Internal Medicine on January 20, showing that glucagon-like peptide-1 (GLP-1) receptor agonists like Ozempic carry an 8.2% higher risk of chronic kidney disease than sodium-glucose cotransporter-2 (SGLT2) inhibitors

The SURMOUNT-1 trial showed average weight loss of 20.2 percent at 72 weeks on the highest dose, a figure that stunned the medical community when it was first published

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The compound works primarily by activating an enzyme called AMP-activated protein kinase (AMPK), which influences glucose metabolism, lipid regulation, and cellular energy balance

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Understanding why this happens is the first step toward figuring out what to do about it