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A significant proportion of the published work comes from a single research group the Zagreb laboratory associated with Sikiric and colleagues

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[3] [8] Patients receiving B12 injections should inform their healthcare provider of all medications, as certain drugs (including metformin, proton pump inhibitors, and chloramphenicol) can affect B12 absorption or metabolism

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Particularly noteworthy is that FOXO4 influences not only lifespan but also the quality of aging through its interaction with the protein p53commonly referred to as the "guardian of the genome." This interaction regulates whether cells remain in a senescent, metabolically inactive state or undergo programmed cell death (apoptosis)

not simply the form of B12 that is 'active' and can therefore be 'used' by the body