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Systemic copper accumulation is unlikely at standard research doses
Despite this, temporarily and reversibly increasing intestinal permeability with permeation enhancers (PE) has proved a beneficial strategy in creating oral formulations of several therapeutic peptides that have been approved by the regulatory authorities for systemic delivery (Lewis et al., 2022)
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doi: 10.1016/S0140-6736(20)32549-6 3 KormanNJ
This creates separation between the two compounds and makes it easier to identify any site-specific reactions
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