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Candidates must meet specific criteria to ensure their suitability and minimize risks

Phase 1a studies in healthy volunteers, published in Diabetes, Obesity and Metabolism in 2023, established the compound's single-dose and multiple-dose pharmacokinetics, confirming a half-life supportive of once-daily dosing, a favorable food-effect profile, and dose-proportional exposure across the tested range

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Transition protocols commonly use a 1 or 2 mg retatrutide bridge regardless of the prior tirzepatide dose

Duration of each program will vary and is based on frequency of the personalized dosing schedule