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Its important physiological role was initially discerned in undifferentiated human embryonic stem cells (hESCs), where ChaC2 is prominently expressed and maintains cell self-renewal and pluripotency by modulating GSH homeostasis

To increase ceramides, use topical moisturizers with ceramide NP, AP, or EOP alongside supporting ingredients like niacinamide, fatty acids, and vitamin C

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Rozman D, Strmstedt M, Tsui LC, Scherer SW, Waterman MR

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Interaction of glucose sensing and leptin action in the brain - PubMed