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Glucagon is also thought to increase energy expenditure, possibly via increased brown adipose tissue activity (Baggio and Drucker, 2021)

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Currently, seven AOMs are approved by both the Food and Drug Administration (FDA) and European Medicines Agency (EMA) -liraglutide, semaglutide, tirzepatide, orlistat, naltrexone/bupropion, setmelanotide, and metreleptin- while two additional agents (phentermine and phentermine/topiramate) are FDA-approved only

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doi: 10.3390/biomedicines11061770 53 XuRWuBLiangJHeFGuWLiKet al