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STEP and SELECT Trial Data, What Researchers Are Working From The pivotal STEP 1 trial (Wilding et al., NEJM 2021, NCT03548935) enrolled 1,961 adults with obesity (no T2D) over 68 weeks at the 2.4mg/week dose

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The phase 1 data described in the same paper indicated that the molecule reached steady-state concentrations consistent with an extended dosing interval and was associated with dose-dependent changes in pharmacodynamic markers of incretin receptor engagement

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AMPK and its Activator Berberine in the Treatment of Neurodegenerative Diseases