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Importantly, persistently high serum B12 in the absence of supplementation should prompt GP assessment, as it may indicate underlying disease processes
Ensure you begin with the lowest dose and wait 4 weeks before increasing it
At the same time, multiple blockbuster GLP-1 therapies are already on the market (Ozempic, Wegovy, and Mounjaro), with numerous next-generation analogues and combination incretin therapies currently in development
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Gastrointestinal Adverse Reactions In the pool of placebo-controlled trials, gastrointestinal adverse reactions occurred more frequently among patients who received semaglutide tablets than placebo: semaglutide tablets 14 mg once daily (41%), semaglutide tablets 7 mg once daily (32%) and placebo (21%), including severe reactions (semaglutide tablets 14 mg 2.0%, semaglutide tablets 7 mg 0.6%, placebo 0.3%)
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