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In the nine GCs tested, the mean peak ratio of Fura-2 (F340/F380) after exendin-4 perfusion was 1.93 0.11, which was significantly higher than that in Ringers (1.08 0.07, P 0.05) (Fig

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Cells were then washed once with HBSS before application of alkaline TNE buffer (pH 8.6) containing (or not) 100 mM Mesna for 5 min at 4C to cleave residual surface GLP-1R

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