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It acts as a GLP-1 receptor agonist, which means it stimulates the action of the glucagon-like peptide-1 (GLP-1) hormone

Immediate medical attention is warranted for severe abdominal pain (possible pancreatitis), persistent vomiting with inability to tolerate oral intake (risk of dehydration and acute kidney injury), or symptoms of gallbladder disease such as right upper quadrant pain, particularly after meals

Ruiz-Ojeda, F

However, this sensation can be intense at the beginning, sometimes bordering on discomfort

The biggest biological difference: Semaglutide acts through GLP-1 activity, while tirzepatide acts through both GIP and GLP-1 activity

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