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J Vet Pharmacol Therap
We further hypothesized that the signaling-effects reported here should lead to a reduction in PGE 2 as proposed in Fig
In other words, lots of different or pleiotropic effects
Results showed that the ingredient significantly increased NAD+ levels in senescent fibroblasts, activated the SIRT1 signaling pathway, reduced the expression of senescence-associated -galactosidase (SA--gal), decreased intracellular reactive oxygen species accumulation, and promoted collagen synthesis
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