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Study location, treatment duration and type of control were detected as sources of heterogeneity following subgroup analysis (Table 2)

Long-term treatment with the dipeptidyl peptidase IV inhibitor P32/98 causes sustained improvements in glucose tolerance, insulin sensitivity, hyperinsulinemia, and beta-cell glucose responsiveness in VDF (fa/fa) Zucker rats

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However, the authors stated this is not a clinically significant difference