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The FDA this week officially confirmed that shortages of Eli Lillys wildly popular GLP-1 drug tirzepatidebranded as Mounjaro for type 2 diabetes and Zepbound for weight managementare over, while the lowest dose of Novo Nordisks competing obesity drug Wegovy still has limited availability
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Consequently, the metabolic pathways initiated by G proteins within GLP-1R involve cAMP activation, extracellular signal-regulated kinases 1 and 2 (ERK 1/2) and increased intracellular calcium levels (17, 19)
Using FDA-cleared sharps containers (rigid, puncture-resistant, labeled) or returning pens to pharmacies ensures needles remain enclosed and safe
For clinicians, understanding and explaining this phenomenon is essential
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