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Tramadol abuse, with its risk of physical dependence, opiate use disorder and overdoses, is of concern worldwide and has led to it being a controlled drug in many countries

Several mechanisms explain how this signaling remains selective: Somatotroph-Specific Signaling Somatotroph cells contain specialized secretory granules that store growth hormone

The most common side effects in trials are gastrointestinal: nausea (around 43% at 12 mg), vomiting (21%), and diarrhoea (33%)

Mueller NT, Koh W-P, Odegaard AO, Gross MD, Yuan J-M, Pereira MA