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The ONTARGET trial (N=25,620) demonstrated that combining an ARB with an ACE inhibitor provided no additional cardiovascular benefit while significantly increasing adverse renal outcomes
These side effects are usually temporary, especially in the first few weeks of treatment, but will go away over time
Diabetes was not a specified inclusion criterion
more recently, glucagon-like peptide 1 receptor agonists (GLP-1RA) and sodium-glucose co-transporter 2 (SGLT-2) inhibitors are recommended independently from metformin for individuals with, or at risk of, CVD, heart failure or chronic kidney disease (CKD), thanks to their benefits for CV and renal outcomes [6]
Hurtado MD, Tama E, Fansa S, Ghusn W, Anazco D, Acosta A, et al
Discovered in the 1970s, it has been extensively studied for its ability to repair tissues, modulate immune responses, and stimulate hair regrowth
