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The reaction is catalyzed by a family of enzymes called Glutathione S-transferases (GSTs), which facilitate a nucleophilic attack, covalently binding the sulfur atom of glutathione directly to the toxic Phase I metabolite

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Oral semaglutide versus subcutaneous liraglutide and placebo in type 2 diabetes (PIONEER 4): a randomised, double-blind, phase 3a trial

10.1016/j.resmic.2010.01.003 Res

The model shows that overexpression of genes on chromosome 21 and an increase in oxidative stress can explain the metabolic profile of Down syndrome