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10.1053/j.gastro.2017.02.004 97

hEDS is characterized by: Loose, unstable joints that dislocate easily Clicking or popping sensations in joints Achy joints and muscles Chronic fatigue Easily bruised skin Digestive issues Increased heart rate and dizziness when standing up Urinary incontinence Many of the subtypes of EDS are associated with specific gene mutations that affect collagen synthesis

They are frequently referred to as GHK-Cu in the scientific community

Using next-generation RNA-seq sequencing technology, they confirmed that GHK-Cu modulates the expression of 4,231 genes , of which 2,861 are upregulated and 1,370 are downregulated