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Considerations and concerns While the results are promising, there remain open questions about cost, access, and other tradeoffs

The SELECT trial measured outcomes over years, not weeks

In December 2024, the FDA's Pharmacy Compounding Advisory Committee declined to include it on the 503A bulk drug substances list, meaning compounding pharmacies in the United States cannot legally produce it for individual prescriptions

26 Simultaneous increased activation of multiple auditory system nerve fibers is believed to be an important mechanisms underlying tinnitus

In the SURMOUNT-5 trial, fewer patients stopped tirzepatide due to gastrointestinal side effects (2.7%) compared to semaglutide (5.6%)

I suggest doing a breath test first to confirm it is SIBO, you may also have SIFO (fungal overgrowth)