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Lactate uptake by CD4 + T cells has been implicated in inhibiting migratory capability, essentially arresting T cells in the lactate hi microenvironment ( Figure 1 )

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In turn, cytokines and chemokines attract and activate inflammatory cells (neutrophils, macrophages, T lymphocytes) within the renal tissue, amplifying the chronic inflammatory response and perpetuating NF-B activation (8487)

Women of childbearing potential should be counseled on avoiding pregnancy while on MB therapy, and if a pregnant patient has a medical emergency like methemoglobinemia, the physician must weigh the maternal benefit against the fetal risk very carefully

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If found to be the case, this peptide may prove to be a relevant molecular model for regeneration-focused studies