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Key evidence considerations include: Gastric emptying effects vary by medication: tirzepatide has more pronounced effects than semaglutide or liraglutide Gastrointestinal side effects (nausea, vomiting, diarrhoea) may independently affect oral contraceptive absorption Individual variation exists in how people respond to these medications Weight loss itself can alter hormone levels and potentially affect fertility Product information for these medications notes that slowed gastric emptying may impact the absorption of oral medicines

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However, the liraglutide group showed a significantly greater increase in fibrous-plaque volume

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