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AD pathogenesis involves a number of interrelated pathways, including amyloid plaque development, tau protein hyperphosphorylation, oxidative stress, neuroinflammation, and metabolic failure (Figure 3)
McGill, G
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The bifunctional enzyme formimidoyltransferase cyclodeaminase (encoded by the FTCD gene) releases monoglutamate 5-forminino-THF from N -formimidoyl-L-glutamate (commonly referred to as FIGLU) and then glutamate and 5,10-methenyl-THF
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