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Haematological symptoms are among the earliest manifestations and include: Fatigue and generalised weakness Pallor due to anaemia (which may be macrocytic, though this is not universal) Shortness of breath on exertion Palpitations or tachycardia Neurological symptoms can be particularly concerning and may include: Peripheral neuropathy with tingling, numbness, or burning sensations in the hands and feet (paraesthesia) Loss of vibration sense and proprioception Ataxia and difficulty with balance or coordination Cognitive impairment, including memory problems and difficulty concentrating Mood disturbances, including depression and irritability In patients with diabetes, distinguishing between diabetic neuropathy and B12 deficiency-related neuropathy can be challenging, as both conditions may coexist
Topics in Organometallic Chemistry
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Animal model research demonstrates that BPC-157 administration reduces tissue inflammation scores by 40-60% across diverse experimental systems including inflammatory bowel disease, musculoskeletal injury, and neuroinflammation models
Patients should remain in the clinic for 10-15 minutes to allow monitoring for delayed anaphylactic reaction
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