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Incretins are defined as nutrient-stimulated gastrointestinal hormones that improve oral glucose tolerance by stimulating insulin secretion

It preserves metabolic rate, improves body composition, enhances insulin sensitivity, and creates a better visual result for the same amount of weight lost

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Therefore, semaglutide is contraindicated in patients with a personal or family history of medullary thyroid carcinoma (MTC) or in patients with Multiple Endocrine Neoplasia syndrome type 2 (MEN 2)

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Bisoprolol is a cardioselective beta-1 blocker, meaning it primarily targets receptors in the heart, reducing heart rate and the force of cardiac contractions