Standard dosing involves a process called titration, which is a form of dose escalation designed to slowly introduce the drug to the body, helping to reduce side effects
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B1 and marginal zone B cells but not follicular B2 cells require Gpx4 to prevent lipid peroxidation and ferroptosis
The cell suspensions were washed twice with ice-cold PBS before staining using an Annexin V/PI staining kit (Alexa Fluor 488 annexin V/Dead Cell Apoptosis Kit)