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86 In patients with T2D and high cardiovascular risk, semaglutide use has resulted in fewer serious cardiac and kidney disorders compared to placebo but is linked to worsening diabetic retinopathy, likely due to rapid glucose reduction

11 12 GLP-1s lower blood sugar, blood pressure, body weight, and inflammationall of which reduce strain on the heart and blood vessels 13 GLP-1 receptors are found in the heart and arteries, where they may also improve endothelial function, increase nitric oxide, and reduce oxidative stress, helping stabilize plaque and improve how the heart uses energy, especially during stress

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But remember that these things are complicated, and multifactorial

Works centrally rather than vascularly (vs

Skin healing potential of bioactive components from Lycoperdon lividum mushroom versus -sitosterol in rat model of burn wounds