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Due to risks for decreased bioavailability of birth control pills, the manufacturer of Mounjaro (tirzepatide) recommends that patients either use barrier contraception for four weeks after initiation or dosage increase or switch to a non-oral contraceptive

But these issues usually resolve within a few weeks, according to Dr

This level of convenience has profound implications for long-term therapy

Rare but serious risks include pulmonary hypertension, valvular heart disease, significantly high blood pressure, arrhythmias, and psychosis in predisposed individuals

Variants in FTO , GLP1R (the GLP-1 receptor itself), MC4R , and TCF7L2 describe the baseline appetite and energy-balance biology any GLP-1 compound acts on

This may increase the risk of residual gastric contents despite preoperative fasting