Key Nutrients Depleted by Corticosteroids Corticosteroids are associated with depletion of multiple nutrients essential for tissue repair, immune defense, and metabolic stability, including: Calcium, vitamin D, magnesium, potassium, zinc, selenium, vitamin C, and protein (1) Mechanisms of Steroid-Induced Nutrient Depletion Calcium & vitamin D: Reduced intestinal absorption and increased urinary loss osteopenia and fracture risk Zinc, selenium & vitamin C: Impaired immune function, delayed wound healing, increased infection risk Protein: Accelerated protein breakdown muscle wasting and connective tissue weakness Magnesium & potassium: Electrolyte imbalance fatigue, weakness, and cardiac rhythm disturbances Why Steroid-Induced Nutrient Depletion Impairs Healing By chronically elevating cortisol signaling, corticosteroids shift the body into a catabolic, stress-dominant state

26 Certain GLP-1 agonist drugs have been associated with a significantly increased risk of depression and anxiety, 27 highlighting an emerging need for complimentary therapies to support patients mental and emotional health while undergoing pharmaceutical GLP-1 therapy
Herrera-Vsquez et al., 2015
Vitamin B12 monitoring is particularly important for patients also taking metformin, as both medications can affect B12 status
The potential increases with continued exposure to solvents, chemicals, and sunlight
The carotenoid may act as an antioxidant and lower inflammation