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These agents bind to GLP-1 receptors in the pancreas, enhancing glucose-dependent insulin secretion and suppressing glucagon release
A narrative review conducted by Trujillo investigated the relative risks for associated adverse effects (such as GI symptoms, hypoglycemia, injection-site reactions, pancreatitis, neoplasms, gallbladder disease, and diabetic retinopathy) among three GLP-1 RAs when injected once weekly
Phase 3 trials of retatrutide named the Triumph trials will provide invaluable insights into the long term weight-loss results of retatrutide as well as its potential impact on obesity-related conditions, such as osteoarthritis and obstructive sleep apnea
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