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That separation is the pharmacological reason the combination is rational

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Fumarate is involved in these functions whether there are pre-existing mutations in the FH gene or not

Mouse islets were incubated in KRBH buffer supplemented with 3 mM glucose for 1 hour followed by stimulation in KRBH buffer supplemented with 11 mM glucose +/ 100 nM exendin-4 for 30 minutes