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267 Claudin-7 (Cldn-7), a member of the tight junction protein family, is closely related to inflammation and tumor development, and Cldn-7 deficiency can significantly upregulate the expression of -catenin and its downstream target genes c-myc and cyclin D1 by promoting aberrant activation of the Wnt/-catenin pathway, which in turn leads to abnormal cell proliferation and tumorigenesis
doi:10.1016/j.jhep.2017.05.009
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Injectable GHK-Cu delivers copper directly into tissue, potentially contributing to total body copper load
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