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One additional study was excluded from quantitative analysis as full results could not be obtained
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This reflects the broader GLP-1 microbiome connection, in which GLP-1 regulation is tightly linked to gut barrier integrity, microbial diversity, and mucin-degrading bacteria such as Akkermansia muciniphila
Potential adverse effects of these drugs include hypoglycemia (when taken with insulin), GI distress, and injection site reactions
Further investigations can include a validation study of the genes involved in the skin irritation mechanism following direct treatment to cells
Effect of GLYHIS-LYS and its copper complex on TGF- secretion in normal human dermal fibroblasts
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