Available from: Trial Registration Number: NCT02637284 Seiwerth S, Milavic M, Vukojevic J, Gojkovic S, Krezic I, Vuletic LB, Pavlov KH, Petrovic A, Sikiric S, Vranes H, Prtoric A, Zizek H, Durasin T, Dobric I, Staresinic M, Strbe S, Knezevic M, Sola M, Kokot A, Sever M, Lovric E, Skrtic A, Blagaic AB, Sikiric P
Patient Management and Practical Recommendations Pre-Treatment Tests B12 and Biomarker Panel: Baseline blood tests checking Vitamin B12, Folate, Methylmalonic Acid (MMA), and Homocysteine levels to confirm the exact type and severity of the deficiency
Peptides containing oxidation-sensitive residues like methionine or cysteine may have somewhat shorter refrigerated shelf lives
Fatal hypokalemia may occur when severe megaloblastic anemia is treated intensively with vitamin B12, as a result of increased erythrocyte potassium requirements
Lyophilized TB-500 Storage Key rule for lyophilized TB-500: Same core principles as BPC-157, with added emphasis on light protection
Vitamin B12 is bonded to and globulins in the blood to the whole body, most of which are distributed over the liver