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Surgical closure may be needed in patients with a large secundum ASD that is not amenable to trans-catheter closure or other types of ASD as they are unlikely to close spontaneously

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Melanotan-I is a prescription drug used to treat a rare incurable genetic disorder, but Melanotan-II is not approved by the TGA and its development as a potential medication was halted years ago due to safety concerns

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Weight loss accelerates during this period, which compounds the glucose benefits

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