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The Evidence: While some botanicals show promise in early studies (e.g., polyphenol-rich fruits, herbs), most have not been rigorously studied in human trials focusing on GLP-1

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Amgen is developing a GLP-1/GIP dual agonist called MariTide (currently in phase 3 trials expected to complete in 2027), which is administered as a once-monthly injection

mPTP opening results in mitochondrial calcium overload, release of cytochrome C, a process involved in apoptosis and implicated in myocardial ischemia-reperfusion (IR) injury (80)