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In conclusion, liraglutide (Saxenda) is approved for adults with a BMI of 30 kg/m2 or greater, or a BMI of 27 kg/m2 or greater with at least one weight-related condition, as an adjunct to a reduced-calorie diet and increased physical activity for chronic weight management

Int J Pharm Pract 2022;30(6):548-553 2

Reduced calorie intake due to appetite suppression when taking semaglutide has been linked to statistically significant weight decreases in both diabetic and non-diabetic trial participants [6, 7]

377 Chronotype appears to have genetic and epigenetic underpinnings and varies with age and between genders

Not all "nighttime" windows are equal

Specifically, GIP is synthesized by the K cells in the upper intestine, while GLP-1 is generated by the L cells in the lower intestine