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We have learned that many of the GLP-1 benefits in humans are also weight-loss independent, which is fascinating. Even albiglutide (Tanzeum, GlaxoSmithKline), which was taken off the market because it wasnt as good as other GLP-1s at reducing glucose and weight, reduced risk for major adverse cardiovascular events (MACE) by 22% compared with placebo despite no difference between the groups in weight loss, he said

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Each time semaglutide dose increases, expect glucose to drop further Proactively reduce basal insulin by 10% with each semaglutide escalation Continue daily glucose monitoring through titration Step 5: Maintenance phase (after reaching target semaglutide dose)

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