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(20) In contrast, Hansen et al
Risk reductions persisted in subgroups with concomitant metformin or insulin use
The strong result comes after Lilly posted equally impressive results with retatrutide in people living with overweight/obesity and knee osteoarthritis in the TRIUMPH-4 study, and in type 2 diabetes patients in the TRANSCEND-T2D-1 trial, building the case for the drug as one of the major new medications in the cardiometabolic category
It helps transport fatty acids into the mitochondria and provides a propionyl group involved in energy-generating pathways
The Wegovy labeling directs clinicians to "monitor renal function in patients reporting adverse reactions to WEGOVY that could lead to volume depletion, especially during dosage initiation and escalation." Volume depletion from persistent gastrointestinal losses can precipitate acute kidney injury, and that risk is higher in people with existing kidney impairment or on medications that affect renal perfusion
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