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This study is to explore a GSH-responsive AP probe-net, which can be activated by the abundant GSH in ATC cells to generate reactive alkoxyamine, and the formed alkoxyamine can trap AP sites and block the APE1 activity, leading to ATC cell death but less adverse effects towards normal cells
Quick takeaways It's a natural defender: Glutathione (GSH) is a powerful tripeptide antioxidant your body produces to combat oxidative stress and neutralize free radicals
Furthermore, potent immunomodulators risk off-target immune activation and systemic cytokine storms if nanocarrier biodistribution is suboptimal (54)
Exp Brain Res (2006) 175(3):37799
Research has shown that a liposomal form of glutathione that can be held under the tongue for sublingual absorption is an effective delivery method that increases blood levels of glutathione
Glutathione is recruited into the nucleus in early phases of cell proliferation
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