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That signal is preclinical only : Dihexa has never entered a human clinical trial, several of the foundational mechanism papers were retracted in 2025 for falsified/fabricated data [4] , and everything below reflects animal reference data and community conventions provided strictly for research and educational reference not medical advice or a recommendation to self-administer
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Furthermore, it mitigated the aggravating effects of L-NAME and L-arginine on convulsions, suggesting a potential non-NO-system involvement in its therapeutic effects
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